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Reith Lectures 2001: The End of Aging - Prof. Tom Kirkwood produces a new and radical interpretation of the ageing process. Standing traditional thinking on its head, he argues that our cells are not programmed to die. We are programmed for survival.
"The longevity revolution has reached a turning-point. The decisions we take in the next few years will have far-reaching consequences for the state of future society."
Immortality Institute - a nonprofit educational organization to help everyone learn more about the possibility of extreme life extension. Immortality News and Forum.|
"Broken Limits to Life Expectancy" - "Is life expectancy [HN1] approaching its limit? Many--including individuals planning their retirement and officials responsible for health and social policy--believe it is. The evidence suggests otherwise." Article in Acrobat Reader PDF format.|
|"Ripping Off the Reaper: Can Human Aging Be Reversed -- And Should It Be?" by R. Garrison - "But as we all know, no matter what you do to thwart Mother Nature, Father Time eventually catches up with you. There seems to be a wall out there, somewhere around 120 years; beyond that, apparently, no one has ever survived. That is, until now..."|
|"Do You Want to Live Forever?" by Sherwin Nuland in Technology Review, 02/2005 - "Aubrey David Nicholas Jasper de Grey is convinced that he has formulated the theoretical means by which human beings might live thousands of years—indefinitely, in fact. Perhaps theoretical is too small a word. De Grey has mapped out his proposed course in such detail that he believes it may be possible for his objective to be achieved within as short a period as 25 years, in time for many readers of Technology Review to avail themselves of its formulations—and, not incidentally, in time for his 41-year-old self as well. (...) De Grey is a familiar figure at meetings of scientific societies, where he has earned the respect of many gerontologists and that new variety of theoreticians known as “futurists.” Not only has his work put him at the forefront of a field that might best be called theoretical biogerontology, but he swims close enough to the mainstream that some of its foremost researchers have agreed to add their names to his papers and letters as coauthors, although they may not agree with the full range of his thinking. Among the most prominent are such highly regarded figures as Bruce Ames of the University of California and the University of Chicago’s Leonid Gavrilov and S. Jay Olshansky. Their attitude toward de Grey is perhaps best expressed by Olshansky, who is a senior research scientist in epidemiology and biostatistics: “I’m a big fan of Aubrey; I love debating him. We need him. He challenges us and makes us expand our way of thinking. I disagree with his conclusions, but in science that’s okay. That’s what advances the field.” De Grey has by his vigorous efforts brought together a cohort of responsible scientists who see just enough theoretical value in his work to justify not only their engagement but also their cautious encouragement. As Gregory Stock, a futurist of biologic technology currently at UCLA, pointed out to me, de Grey’s proposals create scientific and public interest in every aspect of the biology of aging. Stock, too, has lent his name to several of de Grey’s papers."|
|"Be Sane about Antiaging Science" by TR Staff in Technology Review, 02/2005 - "De Grey, who lectures and publishes widely on the topic, claims that by “perturbing” our cellular processes, we could live for thousands and thousands of years. Further, he says that we will be able to do this 25 to 100 years from now. Is this absurd? Yes, of course it is. Yet recent breakthroughs in molecular biology and genetics have created an exciting new field called biogerontology that promises to explain why organisms age. And for the first time, serious scientists can imagine ways to actively alter this process.
|"Aubrey de Grey Responds" by Aubrey D.N.J. de Grey in Technology Review Online - "Dr. Sherwin Nuland's article covers three topics: (a) me, (b) the desirability of greatly postponing aging, and (c) the feasibility of doing so. In the time he and I spent together we discussed (c) very little indeed, not least because, as a physician rather than a biologist, Nuland well appreciated that he is not equipped to evaluate the difficulty of developing technologies that even I do not expect to be available to humans for at least 20 years. (...)|
What can we conclude, observing three such egregious departures from normal logical standards by educated adults? I can identify only one explanation: most of society is in a pro-aging trance. This is no surprise: after all, aging is extremely horrible and until a few years ago could indeed be regarded as probably immutable for a very long time indeed. Hence, a reasonable tactic was to put its horror out of one's mind, however absurd the logical contortions required."
|"Methuselah Man" by D. Appell in Technology Review -|
"TR: You believe that tripling the remaining lifespan of two-year old mice is as little as 10 years away.
De Grey: That's right, with adequate funding. The sort of funding that I tend to talk about is pretty modest, really-less than the amount the United States already spends on the basic biology of aging. I'm talking about a maximum of $100 million per year for 10 years. With that sort of money, my estimate is we would have a 90 percent chance of success in producing such mice.
TR: How could this apply to the general human population?
De Grey: My argument says that if you're young enough, and we fix human aging soon enough, then we will be able to extend your lifetime to 150 years. Then basically we're going to be able to get you out to infinity, depending on your not walking in front of buses and stuff like that. "
|"SENS (Strategies for Engineered Negligible Senescence)" A. de Grey homepage - "SENS is a detailed plan for curing human aging. SENS is an engineering project, in the same way that medicine is a branch of engineering. The key to SENS is the appreciation that aging is best viewed as a set of progressive changes in body composition at the molecular and cellular level, caused as side-effects of essential metabolic processes. These changes are therefore best thought of as an accumulation of "damage", which becomes pathogenic above a certain threshold of abundance. The traditional gerontological approach to life extension, namely to try to slow down this accumulation of damage, is a misguided strategy, firstly because it requires us to improve biological processes that we do not adequately understand, and secondly because it can even in principle only retard aging rather than reverse it. An even more short-termist alternative is the geriatric approach, namely to try to stave off pathology in the face of accumulating damage; this is a losing battle because the continuing accumulation of damage makes pathology more and more inescapable. Instead, the engineering (SENS) strategy is not to interfere with metabolism per se, but to repair or obviate the accumulating damage and thereby indefinitely postpone the age at which it reaches pathogenic levels."|
|"Rejuvenation Research" publisher: Mary Ann Liebert, Inc. of New York - "Rejuvenation Research (formerly Journal of Anti-Aging Medicine) is an international, interdisciplinary, peer-reviewed academic journal that publishes leading work on the implementation of rejuvenation therapies in the laboratory and eventually in the clinic, as well as basic research relevant to the further elucidation of what such therapies must do at the molecular and cellular level in order to be truly effective. Sociopolitical and ethical issues relating to substantial extension of healthy human life expectancy are also covered."|
|"Rejuvenation Research" - Editorial by Aubrey D.N.J. de Grey, Ph.D., Editor-in-Chief - "RR will emphasize research with relevance to modulation of the aging process, especially in mammals. While intervention is the topic of some articles in existing biogerontology journals, it is greatly outweighed by studies aimed at a more detailed understanding of the mechanisms of aging. The opposite emphasis will characterize this journal. Moreover, a particular (though not exclusive) interest of RR—reflected unambiguously in its title—will be studies relevant to lateonset interventions, designed to extend the remaining healthy lifespan of mammals that have not received any treatment until an age at which the symptoms of senescence are already becoming apparent."|
|"An Engineer’s Approach to the Development of Real Anti-Aging Medicine" by Aubrey D.N.J. de Grey - "Abstract: In this Viewpoint, I list the various age-related molecular and cellular changes that are thought to limit mammalian life-span and outline a problem-solving approach to reversing these detrimental changes. This approach should help to prevent the development of these age-related changes into lifethreatening pathologies and, possibly, in due course, allow a large increase in healthy human life expectancy."|
http://sageke.sciencemag.org/cgi/content/full/sageke;2003/1/vp1 - Science's SAGE KE, an online resource for researchers in the field of aging
|"Escape Velocity: Why the Prospect of Extreme Human Life Extension Matters Now" by Aubrey D.N.J. de Grey in PLOS Biology about book "Coping with Methuselah" - "Coping with Methuselah consists of seven essays, mostly on the economics of life extension but also including one essay surveying the biology of aging and one on the ethics of life extension. The economic issues addressed are wide ranging, including detailed analysis of the balance between wealth creation by the employed and wealth consumption in pensions and health care; most chapters focus on the United States, but the closing chapter discusses these issues in a global context. Each essay is followed by a short commentary by another distinguished author. Within their own scope, all of these contributions are highly informative and rigorous. Dishearteningly, however, all echo Sinclair's views about the limited prospects for life extension in the coming decades. In my opinion, they make three distinct oversights."|
|"The Anti-Aging Pill" WBUR Radio Show with David Sinclair, Assistant Professor, Department of Pathology, Harvard Medical School and Leon Kass, chairman, President's Council on Bioethics and author,"The Defense of Dignity: The Challenge for Bioethics" - "(...) For hundreds of years, explorers, scientists, and mad inventors have sought a magic pill that would extend life beyond its normal limits. (...)|
But today, in labs across the country, scientists are discovering ways to extend life, at least for yeast cells, worms, and mice, and many are promising that human beings will be next. Pharmaceutical companies are investing millions of dollars to develop a pill which could extend healthy human life spans by a quarter century or more. A potential boom in centenarians would change society and the way we view our own lives."
World law state
|Platform Planet Earth - A World Citizens Manifesto (D, E).|
Lasset uns Menschen machen ... - Vortrag über 3 Themen der Gentechnik:
1) Was sind die biologischen Grundlagen? Was verstehen wir heute unter Gentechnik? 2) Wer bestimmt was gemacht werden darf?
|"Dem Sensenmann entkommen: Kann menschliches Altern verhindert werden - und sollte dies geschehen?" - "Wie wir jedoch alle wissen: ungeachtet dessen, was wir auch tun, um Mutter Natur zu überlisten - die Zeit holt uns doch schließlich alle ein. Irgendwo scheint eine Mauer zu sein, so etwa bei 120 Jahren; wie es scheint, hat darüber hinaus niemand bisher überlebt. Das heißt, bis jetzt..."|
|Methusalem.com - "Methusalem möchte über Entwicklungen auf dem Gebiet der Gesundheit und Langlebigkeit informieren und Sie mit Tatsachen, Thesen und Tips für ein langes, gesundes Leben unterstützen."|
Förderverein für Alternsforschung, Lebensverlängerung und Kryonik (FALK e.V.) - "Die erstaunlichen Erkenntnisse, die Wissenschaftler über das Altern und Sterben gemacht haben. "
Lebensverlängerung durch Genforschung, Gentechnik und andere molekularbiologische Eingriffe in die Erbsubstanz (DNS / DNA, Chromosomen) +++ Lebensverlängerung durch Megavitamindosen, Antioxidantien, Mineralien und Enzyme +++ Kryonik / Cryonic (Aufbewahrung nach dem Tod in flüssigem Stickstoff) +++ verwandte Themen +++ bestehende Organisationen zu diesen Themen +++ Andere
"Putschisten im Labor. Über die neueste Revolution in den Wissenschaften." - Von Hans Magnus Enzensberger
"Alles in allem handelt es sich dabei um eine Serie von kalten Putschversuchen, mit dem Ziel, alle demokratischen Entscheidungsprozesse auszuhebeln. Die mit der Industrie verschmolzene Wissenschaft tritt als höhere Gewalt auf, die über die Zukunft der Gesellschaft verfügt. ... Die vorlautesten unter ihren Protagonisten erklären jedem, der es hören will, dass sie keinesfalls bereit sind, gesetzliche Einschränkungen hinzunehmen. Sie verkünden ganz offen, dass sie die Absicht haben, ihre Tätigkeit notfalls, nach dem Vorbild von Geldwäschern und Waffenhändlern, in Gegenden fortzusetzen, wo Skrupel unbekannt und Sanktionen nicht zu befürchten sind. "
"So werden jedes Mal, bevor ein Parlament sich mit biopolitischen Fragen befasst, im Fernsehen bedauernswerte Patienten vorgeführt, die an seltenen Erbkrankheiten leiden. Wer wollte ihnen die nötige Hilfe verweigern? Wer möchte es an Bewunderung fehlen lassen für eine Industrie, die bereit ist, Milliarden zu investieren, um deren Los, wenn auch nur in ferner Zukunft, zu erleichtern? Der therapeutische Imperativ wäre allerdings glaubhafter, wenn er es mit Krankheiten wie der Malaria oder der Tuberkulose aufnähme, an denen Jahr für Jahr Millionen sterben, deren Bekämpfung aber kaum vom Fleck kommt. Hier scheint die viel berufene Güterabwägung keine Rolle zu spielen. Das legt den Verdacht nahe, dass es weniger um den hippokratischen Eid geht als um ein wesentlich zukunftsträchtigeres Projekt: die Umzüchtung der Spezies. "
"Die Abschaffung des Sterbens" - Rafaela von Bredow über die Forschung von Aubrey D.N.J. de Grey:|
**Ein Wahnsinniger? Immerhin widmete das angesehene US-Wissenschaftsmagazin "Technology Review" ihm jüngst sogar eine Titelgeschichte: "Ob man ihn nun für einen brillanten und prophetischen Architekten der futuristischen Biologie hält", heißt es darin, "oder für einen fehlgeleiteten und verrückten Theoretiker - über die erstaunliche Größe seines Intellekts kann es keinen Zweifel geben."
Und die zweite große Gerontologen-Tagung in Cambridge, die de Grey derzeit organisiert, lockt immerhin Forscher vom MIT, von Harvard und Stanford an, darunter Größen wie die US-Stammzellstars Jose Cibelli und Gerald Schatten,(...)
Den Tod um das ein oder andere Jährchen hinauszuzögern erscheint aus de Greys Sicht jedoch als Kinderkram. Er will die Uhr zurückdrehen. "Damit kehren Sie zurück zu einem jugendlicheren Zustand", erklärt er. "Je nachdem, wie oft und wie gründlich Sie sich der Therapie unterziehen, können Sie die Ewigkeit in Ihren Zwanzigern verbringen."**
Religion, Moral, Ethik
|Humanistische AKTION - für mehr Menschlichkeit Gemeinnützige Initiative seit 1994. Autor: Rudolf Kuhr|
|WeltbürgerNetz - Für die ökologische und demokratische Weltföderation. Plattform Planet Erde - Ein Weltbürger-Manifest (D, E)|
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